GO and KEGG analyses on differential genes from GSE7305 showed that the cells were mostly associated with the immune receptor activity, positive regulation of Glycosaminoglycan binding, extracellular matrix structural constituent, transcription coactivator activity, Cell adhesion molecules, Cell cycle, Glutathione metabolism, IL-17 pathway, Human T-cell leukemia virus 1 infection, Human T-cell leukemia virus 1 infection, Estrogen pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, Cholesterol metabolism, actin binding and so on
Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition
However, the other components to consider is motility (i.e
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