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Broadstock, M., Ballard, C

It is reserved for severe acne or for cases not responding to the other treatments discussed

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Promising signals are a starting point for investigation not a substitute for robust human efficacy data

For example, patients with a BMI just below 27 but with significant metabolic dysfunction may still benefit from GLP-1 treatment, though prescribing in these cases is considered off-label and requires additional clinical justification

Diabetes and Cardiovascular Disease: The Potential Benefit of Incretin-Based Therapies