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In another cohort study based on 280,090 term infants born at Kaiser Permanente hospitals in northern California between 2011 and 2019, 7,573 (2.7%) infants that had been exposed to SSRIs in late pregnancy, and 11.2% experienced delayed adaptation (defined as a 5-min Apgar score 5, resuscitation at birth, or the administration of respiratory support owing to admission to the neonatal intensive care unit), compared with 4.4% in the unexposed group

The decline in NAD + levels therefore results in impaired metabolism and mitochondrial function via SIRTs and PGC-1

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10.1007/s12192-007-0008-y

However, the absence of human clinical trials means the relevance and safety of these mechanisms in humans remains unestablished