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In the SURMOUNT 1 Trial (pooling doses), total lean mass was reduced by 8.5 absolute percentage points [15]
waist-high garments may be more effective for severe symptoms Meal timing: Avoid prolonged standing after meals when blood pressure naturally drops Medication timing: Discuss with your healthcare provider whether adjusting the timing of antihypertensive medications might help manage symptoms Patients experiencing gastrointestinal side effects should prioritize fluid and electrolyte replacement
This contrasts with controlled animal model findings, which may not accurately reflect real-world complexities
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