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(4) Furthermore, the oxidative stress imbalance, caused by excessive ROS production, impairs the antioxidant defense system by directly damaging antioxidant enzymes (such as SOD and GPx) and depleting key antioxidant molecules like glutathione, leading to fragmentation of hyaluronic acid in the extracellular matrix and abnormal collagen cross-linking, thereby reducing the mechanical properties of cartilage (6, 22, 23)

This is critical because it allows for a constant production of GSH supplying the needs of all of our tissues

The basal expression levels of GPX4 and TfR1 do not correlate with the sensitivity to RSL3 among PTC cell lines

Important functions, but mechanistically focused

That number comes from randomized clinical research

& Kanai, M