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The overall impression from available evidence is that DSIP appears reasonably well-tolerated with a low incidence of serious adverse effects in the populations and contexts studied, but significant gaps in safety knowledge remain, particularly regarding long-term use, use in specific populations (elderly, children, those with comorbidities), and comprehensive toxicology assessment meeting modern pharmaceutical standards

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In PIONEER 1 and 9 where semaglutide was used as monotherapy, patients were previously treated with diet and exercise, or an OAD (in PIONEER 9) that required a wash-out period

Protective effect of ajoene on acetaminophen-induced hepatic injury in mice