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At the end of the experiment, mice were anesthetized with Avertin (300 mg/kg body weight) after 4 h of fasting

Proteomic analysis of aqueous humor from primary open angle glaucoma patients on drug treatment revealed altered complement activation cascade

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We further validated the analysis of PI3K/AKT pathway-related DEGs using RNA-seq data and found that Sema significantly reduced TAC-induced activation of the transcription factors (Creb5 and NR4a1) (Fig

Second, GSK3 is regulated in a circadian manner and has been linked to bipolar disorder for over two decades since the discovery that lithium, directly and indirectly, inhibits GSK3 activity [77,78,79]