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Shorb knew that the same liver extract was used to treat pernicious anemia (her father-in-law had died from the disease), and concluded that LLD could be developed as an assay method to identify the active compound

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Slices were observed in a Philips CM-10 transmission electron microscope (FEI Italia, 20122 Milan, Italy), and micrographs were recorded on Kodak 4489 film