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The effect of adipose-derived mesenchymal stem cell transplantation on ovarian mitochondrial dysfunction in letrozole-induced polycystic ovary syndrome in rats: the role of PI3K-AKT signaling pathway [J]

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This supports topical efficacy on dermal structures, including fibroblasts

Prx is a Trx-dependent peroxidase with six isoforms, which is localized to cytosol (Prx I, II, V, and VI) mitochondria (Prx III and V), ER (Prx IV), and microsome (Prx V) [43]

A 2023 review in StatPearls notes that doses exceeding 7 mg/kg IV can induce methemoglobinemia, particularly in G6PD-deficient individuals, and 5 mg/kg may risk serotonin syndrome, particularly when combined with serotonergic drugs