Research shows that poor sleep increases inflammatory signaling and pain, and increases depression in RA 19, making next-day fatigue much more intense 2
For individuals experiencing fatigue or lethargy, B12 injections can provide a much-needed energy boost, making it easier to engage in physical activityan essential component of any successful weight loss plan
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References: (1) P B Johansen, J Nowak, C Skjrbk, et al (1999) Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats Growth Hormone & IGF Research, Volume 9, Issue 2, May 1999, Pages 106-113
Additionally, ketamine increases brain-derived neurotrophic factor (BDNF) resulting in neurogenesis and synaptic changes to the central nervous system - both of which are key to neuroplasticity
These byproducts can covalently modify proteins, DNA, and other lipids, exacerbating cellular damage and contributing to the ferroptosis (84, 85)