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For some overloading their system with a mega-dose shot of synthetic B12 can actually make them pretty sick because because they cant clear or convert that form of B12 very well

Nevertheless, regimens comprise of one to multiple times weekly intramuscular injections of 1,000 mcg of cyanocobalamin in the first week then weekly for a duration of four to six weeks, subsequently followed by monthly maintenance injections of the same dosage

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Diarrhea or constipation: Often shows up during escalations