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Studies demonstrate that BAs attenuate lipopolysaccharide (LPS)-induced upregulation of NLRP3, ASC, and Caspase-1, thereby reducing MPO activity, inhibit neutrophil infiltration, and alleviate inflammatory responses (43)

This wide variation is thought to be due to differences in the xenobiotic, the plant species or tissue studied and the time of harvest

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However, major body changes including rapid weight loss or muscle loss can sometimes make underlying spinal issues more noticeable