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By regulating the bioavailability of the type-1 IGF receptor (IGF1R) ligands, IGF-1 and IGF-2, the IGF binding proteins (IGFBP-1 to -6) play essential roles in cancer progression

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Mechanistically, GLP-1 carries out its various functions through a PKA-dependent signaling pathway, which plays a key role in regulating NF-B activation across multiple inflammatory conditions [113, 117,118,119,120]

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