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It was developed from research into melanocortin pathways, which regulate a range of functions including sexual arousal, appetite, and inflammation

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Analysis of LaccID activity on yeast surface Yeast cells expressing surface-displayed LaccID mutants as Aga2p fusions in a pCTCON2 (ref

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its absence is informative but not disqualifying, especially when mechanistic and physiological evidence is otherwise robust (Nelson et al., 2015)