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It manifests as tingling, numbness, or altered skin sensitivity, most commonly in the extremities

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GHK-Cu exerts its effects primarily through gene expression modulation, influencing approximately 31% of the human genome by upregulating genes involved in antioxidant responses, DNA repair, protein metabolism, and cellular growth while downregulating inflammatory mediators, fibrinogen synthesis, and pathological processes including cancer metastasis

195 , 196 , 197 For example, increases in betaamyloid and tau may interrupt the sleepwake cycle, 198 leading to increased sleep fragmentation and wakefulness and decreased slowwave sleep

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Psychiatry 22 , 689702 (2017)