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The cyclic structure of MT-2 makes it a more potent, non-selective agonist across the melanocortin receptor subtypes (MC1R, MC3R, MC4R, MC5R) in research models, whereas Melanotan I is comparatively more selective for MC1R

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Functional/Acquired IGF-I Deficiency - Uncoupling of GHR Signaling to IGF1 Gene Transcription and Maintained GHR Metabolic Signaling Due to Insulin Deficiency Increased GHR signaling in obese children does not generally result in elevated IGF-I, due to negative feedback inhibition of GH

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