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Inadequate repair or continuous damage may cause double-strand breaks in the DNA, though DNA strands can be produced in various ways (46)

Observational data suggest potential involvement in inflammatory modulation, mammalian wound-associated signaling, and processes related to bone and connective tissue repair observed in laboratory settings

Notably, increased levels of 4-HNE and its adducts have frequently been observed in RA patients [40, 45]

Another case involved a 52-year-old woman who had a severe anaphylactic reaction to the injection but tolerated oral Vitamin B12 without issues

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