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Modern IV equipment with air-detection sensors has made this event extremely rare, and fully priming IV tubing before use is the main preventive step

NADH-reductive stress is an emerging hallmark of diverse human pathologies, including primary mitochondrial diseases, cancer, cardiac ischemia/reperfusion injury, insulin resistance, fatty liver and dyslipidemia 411

A research was conducted using MDAMB-231 breast adenocarcinoma cells and deferoxamine (DFO) reported to induce HIF-1 via ERK1/2 phosphorylation pathways which also aid in tumor cell migration and metastasis [60]

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From a research standpoint this is a feature it produces cleaner, more reproducible receptor activation for studying downstream signaling