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Similar antiinflammatory effects of GLP-1 have been reported in human macrophage cell lines (66), and systemic effects of GLP-1 agonists on macrophage infiltration have been previously reported (67)

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Therefore, monitoring thyroid parameters is advised when oral semaglutide is co-administered.45,160 In summary, most of the studied drugs did not show clinically significant DDIs related to delayed gastric emptying caused by GLP-1 RAs or a dual GLP-1/GIP RA administration

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