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These patterns come from trial data and common community reports, not a guarantee

The WHO guideline specifically recommends GLP-1 therapies for adults with obesity, defined as BMI 30 or higher

Nat Med (2002) 8(7):6434.10.1038/nm0702-643 80 TschopMSmileyDLHeimanML

Although no clinical trial has yet evaluated the effect of glitazone therapy on skeletal muscle mass or strength in humans as a standalone therapy, pioglitazone has been tested as an adjunctive therapy in older people with impaired physical function undergoing a weight loss programme

The trachea was cannulated, and animals were mechanically ventilated with room air using a positive pressure ventilator (Harvard rodent ventilator, tidal volume of 1 ml/100 g of body weight, ventilator frequency 60 strokes min 1 for rats, 150 strokes min 1 for mice)