This study has been funded by: : Fondation de la Recherche Mdicale (Equipe FRM DEQ20130326503 to R.J.), Agence Nationale de la Recherche (ANR-2011-BSV1-012-01 MLT2D, ANR-2011-META MELA-BETES, ANR-21-CE18-0023 alloGLP1R) and the Who am I? laboratory of excellence No.ANR-11-LABX-0071 funded by the French Government through its Investments for the Future program operated by The French National Research Agency under grant No.ANR-11-IDEX-0005-01 to R.J
This peptide, which they named 'exendin-4', not only stimulated insulin secretion in the same way as GLP-1 but also had the advantage that it remained active for more than two hours after subcutaneous injection
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Made from the pancreatic islet cells of rats, Madsen wanted to find out how such cells matured and triggered gene expression
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This corresponds to an increase of ~225% of plasma glucagon when corrected for the change in glucose concentration