This PIE is only mediated by GLP1-R
the primary abnormality is thought to be a specific defect of the renal secretory mechanism for potassium, which limits the kaliuretic response to, but not the sodium and chloride reabsorptive effect of, mineralocorticoid
Glucagon receptor stimulation increases energy expenditure and promotes fat oxidation
Most patients can continue treatment by managing these side effects through dose adjustment and dietary modifications
Obesity-related cancers identified in the IARC study include endometrial, esophageal, renal cell, gastric, pancreas, colon/rectal, gallbladder, breast, ovarian, and thyroid cancers as well as meningioma, multiple myeloma
Heaton routinely saw people lose 30-40 lbs on Semaglutide and with some extra effort up 60-80 pounds