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The 5 and 3 targeting regions of the pbgst gene were PCR-amplified using the corresponding primer pairs that produced DNA fragments for pbgst-ko 1A and 1B plasmids as detailed in Supplementary Table S2

SalB inhibits the transcription of pro-collagen genes CoI and Co, and the expression of CTGF, IL-1, and IL-6 by modulating the AKT, MAPK/ERK, and TGF-/Smad signaling pathways (Dai et al., 2015a)

Highly Bioavailable Form Acetylated for better absorption, especially in the brain

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To assess clinical utility, we implemented a hierarchical accuracy metric that assigns partial credit based on the WHO classification hierarchy