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The glutamate residue is linked through its side-chain carboxyl, giving a gamma-glutamyl bond rather than a standard alpha-peptide bond, which is why the molecule resists most intracellular peptidases and is cleaved chiefly by gamma-glutamyl transpeptidase at the cell surface

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The 8-6 votes for BPC-157 and KPV, along with favorable recommendations for TB-500 and MOTS-c, represent a significant pivot in how the federal government approaches these compounds

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