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First, Wegovy and other GLP-1s work pretty consistently with treating insulin resistance, and help with the feeling of being full, explains Dr

May AT, Crowe MS, Blakeney BA et al (2019) Identification of expression and function of the glucagon-like peptide-1 receptor in colonic smooth muscle

Tirzepatide has two: GLP-1 plus GIP, the latter contributing both glycemic control and additional weight effects

For the general population, this is manageable

Patients with renal impairment, G6PD deficiency, congestive heart failure, severe hypotension, or known allergies to any ingredient should not receive a Myers cocktail without specialist review

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