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The potential of acylcarnitine signatures for the early identification of DKD Acylcarnitines as novel biomarkers for early-stage DKD The clinical diagnosis of DKD has traditionally relied on the monitoring of UACR and estimated glomerular filtration rate (eGFR) [139]

The pooled meta-analysis of 14 RCTs showed an increased risk of injection-site reactions with GLP-1RAs vs

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Like albiglutide, it has a lower probability of hypoglycemia and no significant weight loss

The review contextualised native GLP-1 as the reference molecule for the entire dual GIP/GLP-1 receptor agonist research field including tirzepatide (approved) and novel triple agonists targeting GLP-1R, GIPR, and GCGR simultaneously confirming native GLP-1s ongoing research importance as the pharmacological anchor of this rapidly expanding compound class