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acnes play a role in promoting chronic inflammation within the TME (199)

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Source: Mol Syst Biol

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In both in vitro SIRT1 knockout/overexpression (AML12 cells) and in vivo liver-specific SIRT1 knockout models, catalpol alleviates Triptolide-induced liver injury by activating SIRT1, improving mitochondrial dysfunction, and reducing glucose metabolism disorders and oxidative stress (Nie et al., 2024)