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In the PIONEER trial program, oral semaglutide 14 mg produced HbA1c reductions of approximately 1.0-1.4% and weight loss of 3-5 kg at 26-52 weeks, meaningful but below the efficacy achievable with injectable semaglutide 2.4 mg or tirzepatide

Copper metalloprotein delivery (SOD1 is a Cu-Zn enzyme) directly enhances enzymatic ROS dismutation

Regarding platelets, no haemolysis, coagulation, or platelet activation was observed [131]

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For the full picture of what this peptide can and cannot do, the complete AOD 9604 guide covers the evidence in detail, including the specific trial data