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The insulinotropic effects of GLP-1(736) are shared with the GLP-1R agonist exendin-4 [28], which is resistant to degradation by DPP-4 [29]

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It has a high affinity to GLP-1R, strongly activating the GLP-1R Gs cAMP pathway without inducing measurable -arrestin recruitment signaling, which indicates it is a fully biased agonist

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Any larger drops in the first few weeks are predominantly water, glycogen depletion, and reduced food volume in the digestive tract