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Reichert CO, de Freitas FA, Sampaio-Silva J, Rokita-Rosa L, Barros P et al (2020) Ferroptosis mechanisms involved in neurodegenerative diseases

114 In contrast to the stimulation of ATP production by low H 2 S levels, higher H 2 S concentrations inhibit complex IV of the mETC and thereby impair ATP production

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In plants, SOD isozymes are present in the cytosol and mitochondria

These findings collectively establish the Trx1-mTOR axis as an important regulatory mechanism in ferroptosis suppression