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FOXO6, as the most evolutionarily divergent member of this group, exhibits tissue-specific expression, particularly in liver, muscle, and neural tissues, and its effects on insulin signaling significantly differ from the other isoforms

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For instance, valerate can lower intestinal pH, thereby promoting the reduction of Fe + to the more bioavailable Fe + form while simultaneously increasing iron solubility

Given the relatively small sample size, the study may have been underpowered to detect modest but biologically meaningful changes

doi:10.1016/j.ymben.2003.09.001

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