Peroxisome proliferator-activated receptor coactivator 1 (PGC-1) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway
Several studies have shown that SDH-deficient cells exhibit increased tumorigenesis and that this increase is reversed by the addition of -KG, supporting the idea that succinate accumulation contributes to tumorigenesis through epigenetic modification 100
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[DOI] [PMC free article] [PubMed] [Google Scholar] 125.Chandrashekar B.S., Roopa M.S., Kusuma M.R., Madura C., Shenoy C., Narayna N.L., Ghoshal P