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Ferroptosis is triggered by the accumulation of reactive oxygen species (ROS) and lipid peroxidation products, leading to catastrophic cell membrane damage and ultimately cell death [7, 8]

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Fe 2 accumulation and reduced GPX4 levels were observed in monocrotaline-induced PH rats, and Fer-1 improved vascular remodeling and right ventricular function by inhibiting ferroptosis [257]