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In addition, the deubiquitinating enzyme BAP1 can remove monoubiquitination at the lysine 119 site of histone H2A on the SLC7A11 promoter, thereby inhibiting SLC7A11 transcription, further reducing cystine uptake of cells and increasing ferroptosis sensitivity

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J Clin Investig 124(8):34193430 Brauch KM, Karst ML, Herron KJ, de Andrade M, Pellikka PA, Rodeheffer RJ, Michels VV, Olson TM (2009) Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy