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Persistent fatigue is often associated with other symptoms such as dyspnea and cognitive impairment, which significantly impact the affected individuals quality of life and functional status (37)

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MI, by mitigating IR, decreases insulin-driven thecal cell steroidogenesis and hepatic inhibition of sex hormone-binding globulin (SHBG), effectively reducing free androgen bioavailability (228)

Niacin is used clinically to increase HDL cholesterol and decrease LDL cholesterol levels [22]

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The acylcarnitine mix solution and the Fatty acid-BSA conjugate were combined to make the final treatment solution with a final concentration of 5 M TMAO, 10 M L-carnitine, 10 nM C6:0-CAR, 10 nM C12:0-CAR, 1 mM UC13-C16:0 and 20 M DHA