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In a pilot trial in patients awaiting gastrointestinal endoscopy or colorectal cancer resection, the administration of a mixture of three major curcuminoids (2.35 g/day for 14 days) resulted in detectable amounts of curcumin in colonic mucosa (mean concentration, 48.4 g/g of tissue), demethoxycurcumin (7.1 g/g), and bisdemethoxycurcumin (0.7 g/g) (78)

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These brain regions include the nucleus accumbens and VTA, which have been identified as targets of Ex-4 actions on brain reward