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Metformin causing vitamin B12 deficiency: a guilty verdict without sufficient evidence

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The TRIUMPH-1 trial showed 24% body weight reduction at 12mg over 48 weeks a number that put the entire GLP-1 space on notice

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Subgroup analyses evaluated four key factors: administration route efficacy, daily dosage, age group and clinical conditions that may affect vitamin B12 metabolism (e.g., underlying pathology)