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The heart: Cardiovascular protection GLP-1 receptor agonists do more than regulate blood sugar they also protect the heart

Successful application of various GLP-1 mimetics to treat type 2 diabetes mellitus (T2DM) and obesity highlights the clinical value of this group of drug targets 3

That means having to know the exact shape of the receptor

Within the brain, tryptophan is initially transformed into serotonin, which is then converted into melatonin through enzymatic reactions requiring B vitamins and magnesium as cofactors

The following table describes GLP-1 receptor agonists, their dosing frequency and key pharmacokinetic parameters: Cautions and Contraindications Adverse Effects Acute pancreatitis (rare) Injection site reactions Gastrointestinal disturbances (nausea, vomiting, diarrhoea dehydration and possible renal impairment) Increase in pancreatic enzymes: lipase and amylase (dulaglutide, tirzepatide and semaglutide) Cholecystitis and cholelithiasis Delayed gastric emptying (semaglutide, exenatide, dulaglutide, tirzepatide (diminishes over time)) Increased heart rate Diabetic retinopathy complications (semaglutide, particularly in insulin-treated patients with known diabetic retinopathy) Interactions GLP-1 receptor agonists do not interact via cytochrome P450 , but delayed gastric emptying may alter drug absorption