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The most common side effects of compounded semaglutide and compounded tirzepatide are similar to their brand-name counterparts and are typically gastrointestinal in nature, including: Nausea Vomiting Diarrhea Constipation Bloating or gas Decreased appetite or early satiety These side effects are usually mild to moderate and tend to improve over time, especially with gradual dose escalation under provider supervision

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Some physicians describe this phenomenon as metabolic whiplash. Shenkman notes that the transition off GLP-1 medications can be challenging for many patients