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While the clinical relevance of these findings in a population largely free from kidney disease remains uncertain, the reductions in albuminuria, blood pressure, and the favourable safety profile support further investigation of retatrutides potential kidney-protective effects in high-risk populations

doi: 10.1016/j.ins.2020.06.025 152

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Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors