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Research suggests that metformin can reduce vitamin B12 absorption in the digestive tract, potentially leading to lower B12 levels over time

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8): a reduced derivative, 200 mg dose of dhBBR exhibits 9.4-fold higher plasma exposure in a randomized, double-blind, crossover fashion with five males (BBR AUC: D200: 929 vs B500: 42.3 ng/mL 120 min) with dose-linear pharmacokinetics in humans comparing with 500 mg dose of BBR (BBR level: B500: 0.4 0.17 ng/mL, D100: 3.76 1.4 ng/mL, D200: 12.0 10.1 ng/mL) [218, 219]