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Methods We performed a systematic literature search identifying articles reporting original data on GLP-1 and pain, including headaches

Important: Retatrutide has not received MHRA approval and is not available in the UK

Treatments addressing these shared pathways, like GLP-1 agonists, may provide dual benefits that single-target approaches cannot match

This includes fewer side effects and a more gradual adaptation for patients who may be sensitive or hesitant

No clinical trial has tested the retatrutide+cagrilintide combination as of May 2026

This has implications for people with fatty liver disease who may not have significant obesity