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(2023) Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action Muller, Neerav et al

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Medications were identified using ATC codes ( Supplemental Table S2 )

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Long-acting formulations, such as dulaglutide, liraglutide, and once-weekly exenatide, have consistently shown superior efficacy in reducing both fasting plasma glucose and HbA1c levels when compared to shorter-acting alternatives like twice-daily exenatide and lixisenatide (Htike et al

Month 1 Summary: What Was Accomplished Weight loss: 2-4 pounds average (1-2% of starting weight) Appetite change: 60-70% report noticeable suppression Side effects: Mild to moderate in 40% of people, minimal in 60% Discontinuation rate: 3-5% stop during month 1 (lowest attrition period) Psychological state: Hopeful but impatient for faster results Key achievement: Body adapted to medication without major complications Reality check: Month 1 is the easiest month