semaglutide and alcohol use disorder A new clinical trial supported by the National Institutes of Health (NIH) found that a medication commonly used for weight loss, such as semaglutide, may also help reduce heavy drinking in individuals Once-weekly semaglutide versus placebo in

This effect can increase sympathetic outflow and potentiate the release of norepinephrine from nerve endings, leading to activation of 1 and 1 receptors in the heart and peripheral vasculature, with a consequent rise in blood pressure Blocks presynaptic 2 adrenergic receptors Indications: Rarely used Sometimes used in the treatment of orthostatic hypotension because it promotes norepinephrine release through blockade of 2 receptors in both the central nervous system and the periphery There is some evidence that it may be possibly effective in treating erectile dysfunction & SSRI related sexual dysfunction in both men & women by unclear mechanisms (NIH Medlineplus) Has been suggested to have aphrodisiac properties Side Effects: Yohimbine exerts a stimulating action on the mood and may increase anxiety Major drug Interactions: Yohimbine can reverse the antihypertensive effects of an 2 receptor agonist such as clonidine, a potentially serious adverse drug interaction References: Biaggioni I (2021): Adrenoceptor Antagonists (Chapter 10)

[Google Scholar] 34

Insulin Potentiation Therapy (IPT) for Cancer Insulin Potentiation Therapy (IPT) is a cutting-edge alternative cancer treatment that combines insulin with chemotherapy to target cancer cells more effectively

Optimize sleep and minimize stress: Poor sleep and chronic stress increase adrenaline and cortisol, both of which can raise your heart rate and make palpitations more frequent

Light pressure with a clean cotton ball or gauze is fine if there is minor bleeding, but vigorous rubbing can spread the medication away from the intended depot and may increase bruising

(1967) Vitamin B12: an aid to oral mucous membrane healing