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Dementia and Alzheimers disease appear to arise from a chronic brain energy crisis, driven by impaired glucose utilization, insulin resistance, mitochondrial dysfunction, vascular insufficiency, and sustained neuroinflammation

One study has found an association between a genetic variation in the SGLT2 gene (the rs9934336 G-allele) and increased plasma glucose and insulin concentrations during an oral glucose tolerance test [75]

In that way PAPS is transformed to adenosine phosphosulfate (APS)