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Stage IIB: The tumor is either: more than 2 but not more than 4 millimeters thick, with ulceration

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Some older studies examined combinations of weaker GLP-1 drugs with DPP-4 inhibitors, showing modest additional glucose lowering compared to either drug alone, but the incremental benefit did not justify the added complexity and cost for most patients

For patients with significant injection anxiety, distraction techniques, topical numbing agents (after consultation with a healthcare provider), or ice application before injection may provide additional comfort

Ilbeigi D, Nourbakhsh M, Pasalar P, Meshkani R, Shokri Afra H, Panahi GH, et al