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[...] Understand how excess weight affects heart disease, life expectancy, and daily functionand how surgical treatment can change the trajectory

Acting on insulin and glucagon levels, incretins, and thus TZP, may have indirect effects also on the liver and muscle (56)

Postoperative pain is the most common complaint, but anal stricture (rare) or incontinence may occur due to excessive tissue excision and damage to the sphincter muscles

Common side effects include mild nausea, fullness, occasional diarrhea or constipation, or reduced appetite that may initially feel stronger than expected

GLP-1 Bridge is a workaround, since it operates outside the Part D benefit, runs on CMSs demonstration authority, and expires on December 31, 2027

All procedures were carried out in accordance with the NIH Guide for Care and Use of Laboratory Animals and institutional guidelines