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Beneficial pharmacological activity of synthetic PGC-1 or PPAR agonists (such as, e.g., fibrates and thiazolidinediones) has been shown, but their adverse effects in various systems are also known [25, 26, 31]

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By sustaining chronic upregulation of HIF-1, synovial hypoxia provides a feed-forward mechanism amplifying synovitis

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The Role of GLP-1 Receptors in the Body The effectiveness of GLP-1 hormones hinges on their interaction with GLP-1 receptors, which are located in several key organs in the body: the brain, pancreas, gut, and liver