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Verspohl EJ, Bauer K, Neddermann E

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ACANTHOSIS NIGRICANS AND OBESITY Patients with AN, especially childhood benign AN, are at risk for obesity, hypertension, hyperinsulinemia, IR and type 2 diabetes and AN may be used as reliable index of IR.[14] But obesity is a more important determinant of IR than AN, hence AN should not be used as exclusive marker for predicting which overweight children have excess insulin levels

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The pharmacokinetics of each peptide should be considered when designing use schedules

Of the 1,283 screened individuals, 223 men and women were enrolled, ranging in age from 18 to 85 years