In the proliferation phase, the proliferation, migration, and secretory functions of fibroblasts, endothelial cells, keratinocytes, and other cells are crucial for wound closure
- 11 2, 10 - 400-10 000 / 8-12
The gut microbiota-brain axis in behaviour and brain disorders
Smart material mechanisms and functional outcomes pH-responsive hydrogels for targeted drug release To address chronic infections and drug-resistant pathogens, stimulus-responsive smart hybrid nanomaterials have emerged as promising therapeutic systems
(Endocrinology, 2010), demonstrated a strong species-dependent effect: In rodents: High GLP-1 receptor expression in thyroid C-cells Strong cAMP signaling activation Persistent stimulation leads to tumor formation In humans and primates: Minimal or absent functional GLP-1 receptor expression in C-cells No meaningful calcitonin elevation under therapeutic exposure No observed C-cell proliferation in long-term studies Even exposure levels far exceeding clinical doses failed to reproduce rodent-like thyroid effects in primate models
The research context is important